City Research Online

Article

Dunbar, H. M. P. ORCID: 0000-0002-7149-5122, Crabb, D. P., Behning, C. ORCID: 0000-0002-9310-3804 , Binns, A. M. ORCID: 0000-0001-8621-498X, Abdirahman, A., Terheyden, J. H., Poor MRCOphth, S. ORCID: 0000-0003-4374-1178, Finger, R. P., Leal, S. ORCID: 0000-0001-7870-0478, Tufail, A., Holz, F. G., Schmid, M. & Luhmann, U. F. O.view all authors (2025). Heterogeneous Visual Function Deficits in Intermediate Age-Related Macular Degeneration: A MACUSTAR Report. Ophthalmology Science, 5(4), article number 100708. doi: 10.1016/j.xops.2025.100708

Terheyden, J. H., Holz, F. G., Behning, C. , Dunbar, H. M. P., Schmitz-Valckenberg, S., Tufail, A., Schmid, M., Crabb, D. P. ORCID: 0000-0001-8611-1155, Saßmannshausen, M., Binns, A. ORCID: 0000-0001-8621-498X, Hoyng, C. B., Zakaria, N., Poor, S., Moll, K-P., Cosette, D., Martinho, C., Batuca, J., Cunha-Vaz, J., Luhmann, U. F. O., Leal, S. & Finger, R. P.view all authors (2025). The Spectrum of Functional, Structural and Patient-Reported Outcomes in Intermediate Age-Related Macular Degeneration – A MACUSTAR Study Report. Ophthalmologica, 248(2), pp. 101-111. doi: 10.1159/000543231

Terheyden, J. H., Dunbar, H. M. P., Schmitz-Valckenberg, S. , Behning, C., Martinho, C., Luhmann, U. F. O., Saßmannshausen, M., Lüning, A., Miliu, A., Aires, I. D., Basile, P. G., Batuca, J., Schmid, M., Moll, K-P., Zakaria, N., Tufail, A., Binns, A., Crabb, D. P. ORCID: 0000-0001-8754-3902, Leal, S., Finger, R. P., Holz, F. G., Agostini, H., Aires, I. D., Altay, L., Atia, R., Bandello, F., Basile, P. G., Batuca, J., Behning, C., Belmouhand, M., Berger, M., Binns, A. ORCID: 0000-0001-8621-498X, Boon, C. J. F., Böttger, M., Brazier, J. E., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cosette, D., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., Dunbar, H., Finger, R. P., Fletcher, E., Gutfleisch, M., Hartgers, F., Higgins, B., Hildebrandt, J., Höck, E., Hogg, R., Holz, F. G., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T. E., Lu, D., Luhmann, U. F. O., Lüning, A., Manivannan, N., Marques, I., Martinho, C., Miliu, A., Moll, K. P., Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Priglinger, S., Ramamirtham, R., Ribeiro, R., Rowen, D., Rubin, G. S., Sahel, J., Sánchez, C., Sander, O., Saßmannshausen, M., Schmid, M., Schmitz-Valckenberg, S., Siedlecki, J., Silva, R., Souied, E., Staurenghi, G., Tavares, J., Taylor, D. J. ORCID: 0000-0001-8261-5225, Terheyden, J. H., Tufail, A., Valmaggia, P., Varano, M., Wolf, A. & Zakaria, N.view all authors (2025). Validating candidate endpoints for intermediate age-related macular degeneration trials in a multi-centre setting—lessons from the MACUSTAR study. Eye, 39(6), pp. 1031-1039. doi: 10.1038/s41433-024-03568-2

Terheyden, J. H., Gittel, L., Jungblut, J. , Taylor, D. J. ORCID: 0000-0001-8261-5225, Holz, F. G., Crabb, D. P. ORCID: 0000-0001-8611-1155 & Finger, R. P.view all authors (2024). Heterogeneity of patient-reported outcome measures in clinical research. Health and Quality of Life Outcomes, 22(1), article number 65. doi: 10.1186/s12955-024-02282-7

Rowen, D., Carlton, J., Terheyden, J. H. , Finger, R. P., Wickramasekera, N., Brazier, J., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A. ORCID: 0000-0001-8621-498X, Boon, C. J. F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P. ORCID: 0000-0001-8611-1155, Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Holz, F. G., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T. E., Luhmann, U. F. O., Lüning, A., Marques, I., Martinho, C., Montesano, G. ORCID: 0000-0002-9148-2804, Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Pfau, M., Poor, S., Priglinger, S., Rowen, D., Rubin, G. S., Sahel, J., Sanches Fernandes, D., Sánchez, C., Sander, O., Saßmannshausen, M., Schmid, M., Schmitz-Valckenberg, S., Schrinner-Fenske, H., Siedlecki, J., Silva, R., Skelly, A., Souied, E., Staurenghi, G., Stöhr, L., Tavares, D., Tavares, J., Taylor, D. J. ORCID: 0000-0001-8261-5225, Terheyden, J. H., Thiele, S., Tufail, A., Varano, M., Vieweg, L., Werner, J., Wintergerst, L., Wolf, A. & Zakaria, N.view all authors (2024). Development and Valuation of a Preference-Weighted Measure in Age-Related Macular Degeneration From the Vision Impairment in Low Luminance Questionnaire—A MACUSTAR Report. Value in Health, 27(5), pp. 642-654. doi: 10.1016/j.jval.2024.02.001

von der Emde, L., Mallwitz, M., Vaisband, M. , Hasenauer, J., Saßmannshausen, M., Terheyden, J. H., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Batuca, J., Behning, C., Belmouhand, M., Berger, M., Binns, A. M. ORCID: 0000-0001-8621-498X, Boon, C. J. F., Böttger, M., Bouchet, C., Brazier, J E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P. ORCID: 0000-0001-8611-1155, Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E, Floyd, H., Francisco, C., Gutfleisch, M., Hinz, S., Hogg, R., Holz, F. G., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T. E., Luhmann, U. F. O., Lüning, A., Marques, I., Martinho, C., Montesano, G. ORCID: 0000-0002-9148-2804, Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Pfau, M., Poor, S., Priglinger, S., Rowen, D., Rubin, G. S., Sahel, J., Sánchez, C., Sander, O., Schmid, M., Schmitz-Valckenberg, S., Siedlecki, J., Silva, R., Skelly, A., Souied, E., Staurenghi, G., Stöhr, L., Taylor, D. J., Terheyden, J. H., Thiele, S., Tufail, A., Varano, M., Vieweg, L., Wintergerst, L., Wolf, A., Zakaria, N., Sloan, K. R., Schmitz-Valckenberg, S., Finger, R. P., Holz, F. G. & Ach, T.view all authors (2023). Retest variability and patient reliability indices of quantitative fundus autofluorescence in age-related macular degeneration: a MACUSTAR study report. Scientific Reports, 13(1), article number 17417. doi: 10.1038/s41598-023-43417-y

Higgins, B. E. ORCID: 0000-0002-4530-6156, Montesano, G. ORCID: 0000-0002-9148-2804, Dunbar, H. M. P. , Binns, A. M. ORCID: 0000-0001-8621-498X, Taylor, D. J. ORCID: 0000-0001-8261-5225, Behning, C., Abdirahman, A., Schmid, M. C., Terheyden, J. H., Zakaria, N., Poor, S., Finger, R. P., Leal, S., Holz, F. G., Rubin, G. S., Luhmann, U. F. O., Crabb, D. P. ORCID: 0000-0001-8611-1155 & MACUSTAR Consortiumview all authors (2023). Test-Retest Variability and Discriminatory Power of Measurements From Microperimetry and Dark Adaptation Assessment in People With Intermediate Age-Related Macular Degeneration - A MACUSTAR Study Report.. Translational Vision Science & Technology, 12(7), article number 19. doi: 10.1167/tvst.12.7.19

Saßmannshausen, M., Behning, C., Weinz, J. , Goerdt, L., Terheyden, J. H., Chang, P., Schmid, M., Poor, S., Zakaria, N., Finger, R. P., Holz, F. G., Pfau, M., Schmitz-Valckenberg, S., Thiele, S., MACUSTAR consortium members, Binns, A. M. ORCID: 0000-0001-8621-498X, Carlton, J., Crabb, D. P. ORCID: 0000-0001-8611-1155, Montesano, G. ORCID: 0000-0002-9148-2804 & Taylor, D. J. ORCID: 0000-0001-8261-5225view all authors (2023). Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration: A MACUSTAR Study Report. Ophthalmology Retina, 7(5), pp. 420-430. doi: 10.1016/j.oret.2022.12.007

Saßmannshausen, M., Behning, C., Isselmann, B. , Schmid, M., Finger, R. P., Holz, F. G., Schmitz-Valckenberg, S., Pfau, M., Thiele, S, Montesano, G., Crabb, D. P. ORCID: 0000-0001-8611-1155 & MACUSTAR Consortiumview all authors (2022). Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report. Scientific Reports, 12(1), article number 14933. doi: 10.1038/s41598-022-18875-5

Dunbar, H. M. P., Behning, C., Abdirahman, A. , Higgins, B. E. ORCID: 0000-0002-4530-6156, Binns, A. M. ORCID: 0000-0001-8621-498X, Terheyden, J. H., Zakaria, N., Poor, S., Finger, R. P., Leal, S., Holz, F. G., Schmid, M., Crabb, D. P. ORCID: 0000-0001-8611-1155, Rubin, G. S. & Luhmann, U. F. O.view all authors (2022). Repeatability and Discriminatory Power of Chart-Based Visual Function Tests in Individuals With Age-Related Macular Degeneration: A MACUSTAR Study Report. JAMA Ophthalmology, 140(8), doi: 10.1001/jamaophthalmol.2022.2113

Ramke, J., Evans, J. R., Habtamu, E. , Mwangi, N., Silva, J. C., Swenor, B. K., Congdon, N., Faal, H. B., Foster, A., Friedman, D. S., Gichuhi, S., Jonas, J. B., Khaw, P. T., Kyari, F., Murthy, G. V. S., Wang, N., Wong, T. Y., Wormald, R., Yusufu, M., Taylor, H., Resnikoff, S., West, S. K., Burton, M. J., Aghaji, A., Adewole, A. T., Csutak, A., Salam, A. S., Paduca, A., Bron, A. M., Denniston, A. K., Lazo Legua, A., Halim, A., Tefera, A. W., Mwangi, A., Jenkins, A. J., Davis, A., Meddeb-Ouertani, A., Wali, A. H., Palis, A. G., Bastos de Carvalho, A., Joshi, A., Kreis, A. J., Mueller, A., Bastawrous, A., Cooper, A., Smith, A. F., Grzybowski, A., Arvind, A., Karanu, A. M., Orlina, A. O., Burnett, A., Yashadhana, A., Abeydeera, A. P., Abdurakhmanova, A., Mohamed, A., Bacchav, A., Bernhisel, A., Webson, A. W., Azuara-Blanco, A., Hossain, A., Ilhan, B., Assumpta Lucienne, B., Tousignant, B., Shamanna, B. R., Wiafe, B., Mueller, B., Caglar, C., Mpyet, C., Abraham, C. H., Cheung, C. Y., Thiel, C. L., Jan, C. L., Emedike, C., Chuluunkhuu, C., Chinyere, C., Henein, C., Gilbert, C. E., Bascaran, C., Nitulescu, C. E., Patel, D., Bachani, D., Kiage, D., Etya'ale, D., Dahdal, D., Woo Lawson, D., Godin, D., Nkanga, D. G., Ondeyo, D. M., O'Brien, D., Mutie, D. M., Alalawi, E. S. K., Mayorga, E., Bin Hashim, E., Ashrafi, E., Kishiki, E. A., Kurian, E., D'Esposito, F., Masila, F., Pena, F. Y., Büsch, F., Topouzis, F., Bandello, F., Oyediji, F. J., Thumann, G., Ezz Elarab, G., Kitema, G. F., Schlenther, G., Fefoame, G. O., Cochrane, G. M., Laganovska, G., Awan, H. R., Ansari, H. M., Philippin, H., Burn, H., Dimaras, H., Filipe, H. P., Monye, H. I., Kandel, H., Randrianarisoa, H. L., Jones, I., Murdoch, I. E., Fabian, I. D., Khan, I. A., Sharma, I. P., Elbeih, I., Mactaggart, I., Pastor, J. C., Keunen, J. E. E., Ohuma, J. A., Pithuwa Nirwoth, J., Hammou, J., Vianna, J. R., Biao, J-E., Burr, J. M., Keenan, J. D., Blijkers, J., Black, J. M., Barbosa Breda, J., Furtado, J. M., Buchan, J. C., Lawrenson, J. ORCID: 0000-0002-2031-6390, Kempen, J. H., Ehrlich, J. R., Stern, J., Zhang, J. H., Keskinbora, K. H., Knoll, K. M., Blanchet, K., Schmid, K. L., Ono, K., Ogundimu, K., Balo, K., Somda, K. P., Yeboah, K., Amissah-Arthur, K. N., Nasehi, L., Øverland, L., Vijaya, L., Keay, L., Hamm, L. M., Mowatt, L., Harrison-Williams, L. C. M., Silva, L., Bilotto, L., Mörchen, M., Rabiu, M., Zondervan, M., Chagunda, M., Sandinha, M. T., Yee Melgar, M., Salas Vargas, M., Daniell, M. D., Katibeh, M., Broom, M., Collins, M. E., Alp, M. N., Kwarteng, M. A., Belkin, M., Gichangi, M., Sylvanowicz, M., Wu, M., Cano, M. R., Shalaby, M., Duggal, M., Khairallah, M., Batur, M., Bikbov, M. M., Ramappa, M., Pamarathi, N., Khachatryan, N., Muhammad, N., Kennedy, N., Murray, N., Beare, N. A. V., Astbury, N., Carnt, N. A., St Rose, N. A., Barker, N. H., Pehere, N. K., Uche, N. J., Lois, N., Awe, O. O., Mujica, O. J., Okolo, O. E., Rani, P. K., Ruamviboonsuk, P., Ndiaye, P. A., Dhakhwa, P., Rozsival, P., Mbulawa, P. K., Keane, P. A., Jones, P. R., Holland, P., Nukella, P. B., Burgess, P. I., O'Dwyer, P. A., Piyasena, P., Bastola, P., Morjaria, P., Nasimee, Q., Rambacal, R. A. T., Das, R., Khandekar, R. B., Azad, R., Bashshur, R., Sousa, R. A. R. C., Oenga, R., Gurung, R., Geneau, R., Jacobs, R. J., Finger, R. P., Guymer, R. H., Sevciuc, R., Khanna, R. C., George, R., Graham, R., Kawasaki, R., Ho, S. M., Mishra, S. K., Buttan, S., Block, S. S., Talero, S., Yoon, S., Joseph, S., Safi, S., Dodson, S., Munoz, S. R., Bakayoko, S., Mohammadi, S. F., Muez, S. A., Pardhan, S., Hopkins, S., Sheu, S-J., Coulibaly, S. M., Schellini, S. A., Arunga, S., Bush, S. R., Sivaprasad, S., Salomao, S. R., Marmamula, S., Onwubiko, S. N., Misra, S. L., Kuyyadiyil, S., Kulkarni, S., khanal, S., Yasmin, S., Pavljasevic, S. N., Gilbert, S. S., Braithwaite, T., Ghidirimschi, T., Ravilla, T., Fricke, T. R., Cogliati, T., Kassa, T., Peto, T., Dibb, U., Lansingh, V. C., Hu, V. H., Sheffield, V. M., Mathenge, W., Dean, W. H., Nolan, W., Hiratsuka, Y., Mahsood, Y. J. & Sapkota, Y.view all authors (2022). Grand Challenges in global eye health: a global prioritisation process using Delphi method. The Lancet Healthy Longevity, 3(1), e31-e41. doi: 10.1016/s2666-7568(21)00302-0

Terheyden, J. H., Behning, C., Lüning, A. , Wintergerst, L., Basile, P., Tavares, D., Melício, B., Leal, S., Weissgerber, G., Luhmann, U. F. O., Crabb, D. P. ORCID: 0000-0001-8754-3902, Tufail, A., Hoyng, C., Berger, M., Schmid, M., Silva, R., Martinho, C., Cunha-Vaz, J., Holz, F. G., Finger, R. P. & MACUSTAR consortiumview all authors (2021). Challenges, facilitators and barriers to screening study participants in early disease stages-experience from the MACUSTAR study. BMC Medical Research Methodology, 21(1), article number 54. doi: 10.1186/s12874-021-01243-8

Terheyden, J. H., Ometto, G., Montesano, G. , Wintergerst, M. W. M., Langner, M., Liu, X., Keane, P. A., Crabb, D. P. ORCID: 0000-0001-8754-3902, Denniston, A. K. & Finger, R. P.view all authors (2021). Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements. Scientific Reports, 11(1), article number 3271. doi: 10.1038/s41598-021-82786-0

Terheyden, J. H., Schmitz-Valckenberg, S., Crabb, D. P. ORCID: 0000-0001-8754-3902 , Dunbar, H., Luhmann, U. F. O., Behning, C., Schmid, M., Pires, I., Cunha-Vaz, J., Tufail, A., Weissgerber, G., Leal, S., Holz, F. G. & Finger, R. P.view all authors (2020). Use of composite endpoints in early and intermediate age-related macular degeneration clinical trials - state-of-the-art and future directions. Ophthalmologica, 244(5), pp. 387-395. doi: 10.1159/000513591

Terheyden, J. H., Holz, F. G., Schmitz-Valckenberg, S. , Lüning, A., Schmid, M., Rubin, G. S., Dunbar, H., Tufail, A., Crabb, D. P. ORCID: 0000-0001-8754-3902, Binns, A. M., Sánchez, C. I., Hoyng, C., Margaron, P., Zakaria, N., Durbin, M., Luhmann, U., Zamiri, P., Cunha-Vaz, J., Martinho, C., Leal, S., Finger, R. P. & MACUSTAR consortiumview all authors (2020). Clinical study protocol for a low-interventional study in intermediate age-related macular degeneration developing novel clinical endpoints for interventional clinical trials with a regulatory and patient access intention-MACUSTAR.. Trials, 21(1), article number 659. doi: 10.1186/s13063-020-04595-6

Finger, R. P., Schmitz-Valckenberg, S., Schmidt, M. , Rubin, G. S., Dunbar, H., Tufail, A., Crabb, D. P. ORCID: 0000-0001-8754-3902, Binns, A. M. ORCID: 0000-0001-8621-498X, Sánchez, C. I., Margaron, P., Normand, G., Durbin, M. K., Luhmann, U. F. O., Zamiri, P., Cunha-Vaz, J., Asmus, F. & Holz, F. G.view all authors (2018). MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration. Ophthalmologica, 241(2), pp. 61-72. doi: 10.1159/000491402

Conference or Workshop Item

Dunbar, H. M. P., Sassmannshausen, M., Behning, C. , Thiele, S., Binns, A. M. ORCID: 0000-0001-8621-498X, Higgins, B. E. ORCID: 0000-0002-4530-6156, Terheyden, J. H., Tufail, A., Leal, S., Zakaria, N., Holz, F. G., Schmid, M., Finger, R. P., Crabb, D. P. ORCID: 0000-0001-8611-1155, Schmitz-Valckenberg, S. & Luhmann, U. F. O.view all authors (2022). Comparison of visual function in structurally defined sub-phenotypes of intermediate AMD: A MACUSTAR study report. In: Investigative Ophthalmology & Visual Science. ARVO Annual Meeting 2022, 1-4 May 2022, Denver, USA.