Automatic segmentation of centromeres, foci and delineation of chromosomes

Hoffmann, E. & Reyes-Aldasoro, C. C. (2015). Automatic segmentation of centromeres, foci and delineation of chromosomes. Paper presented at the Medical Image Understanding and Analysis 2015, 15-7-2015 - 17-7-2015, University of Lincoln.

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Abstract

The observation of chromosomes has been crucial for our understanding of their structure, function, organization, and evolution of genes and genomes as well as morphological changes during mitotic and meiotic divisions. In this work, we present an automatic algorithm for the segmentation of centromeres and foci of DNA processing proteins, as well as the delineation of convoluted chromosomes. The algorithm is fully automatic and does not require tuning of parameters. Statistical measurements of numbers, areas distance and lengths are provided by the algorithm. The work is preliminary as this algorithm has not been tested on a large database nor used to differentiate between populations, however, it is considered that given it is fully automatic and fast it should be a useful tool for the analysis of chromosomes.

Item Type: Conference or Workshop Item (Paper)
Subjects: R Medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: School of Engineering & Mathematical Sciences > Engineering
URI: http://openaccess.city.ac.uk/id/eprint/11967

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