Segmentation and morphological analysis of microvessels in immunostained histological tumour sections

Reyes-Aldasoro, C. C., Williams, L. J., Akerman, S., Kanthou, C. & Tozer, G. M. (2010). Segmentation and morphological analysis of microvessels in immunostained histological tumour sections. Paper presented at the Medical Image Understanding and Analysis, 06-07-2010 - 07-07-2010, Warwick, Uk.

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Abstract

Segmentation and morphological analysis of microvessels in immunostained histological tumour sectionsA fully automatic segmentation and morphological analysis algorithm for the analy- sis of microvessels from CD31 immunostained histological tumour sections is presented. The algorithm exploited the distinctive hues of stained vascular endothelial cells, cell nuclei and background, which provided the seeds for a region-growing algorithm in the 3D Hue, Saturation, Value (HSV) colour model. The segmented objects, identified as microvessels by CD31 immunostaining, were post-processed with three morphological tasks: joining separate objects that were likely to belong to a single vessel, closing ob- jects that had a narrow gap around their periphery, and splitting objects with multiple lumina into individual vessels.

Item Type: Conference or Workshop Item (Paper)
Additional Information: Copyright 2010. The copyright of this document resides with its authors. It may be distributed unchanged freely in print or electronic forms.
Uncontrolled Keywords: vessel segmentation and morphology, IHC
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: School of Engineering & Mathematical Sciences > Engineering
Related URLs:
URI: http://openaccess.city.ac.uk/id/eprint/4644

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