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A cross-national analysis of childhood predictors of physical pain

Macchia, L. ORCID: 0000-0001-9558-4747, Okafor, C. N., Breedlove, T. , Shiba, K., Piper, A., Johnson, B. & VanderWeele, T. J. (2025). A cross-national analysis of childhood predictors of physical pain. Commun Med (Lond), 5(1), article number 337. doi: 10.1038/s43856-025-00997-2

Abstract

BACKGROUND: The socioeconomic, psychosocial, and behavioural factors that influence physical pain have been largely explored. However, evidence on the childhood circumstances that shape physical pain in adulthood is scarce.

METHODS: Using a nationally representative dataset of 202,898 individuals (Age range: 18-99, 49% female, 51% male, 0.03% other) from 22 countries and a random effects meta-analysis, we examine 13 potential childhood predictors of physical pain in adulthood.

RESULTS: We find that childhood experiences, personal attributes, and familial and social circumstances have meaningful and varied associations with adulthood levels of physical pain. Specifically, we find that people whose parents were divorced, single, or died (vs married) when they were children, those who reported that their family found it very difficult to live with their family's household income when they were growing up (vs got by), those who experienced abuse (vs not), felt like an outsider (vs not), reported poor physical health while growing up (vs good) and reported more frequent religious attendance at age 12 (vs never) have a greater risk of experiencing pain later in life. The strength of these associations differs by country reflecting diverse societal influences.

CONCLUSIONS: Our study provides valuable insights on the early-life experiences that shape physical pain in adulthood. These findings enhance our understanding of early-life predictors of adult wellbeing and offer comprehensive evidence for designing interventions to reduce physical pain levels.

Publication Type: Article
Additional Information: This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Publisher Keywords: Epidemiology, Pain
Subjects: R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Departments: School of Health & Medical Sciences
School of Health & Medical Sciences > Department of Psychology & Neuroscience
SWORD Depositor:
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